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Literature summary extracted from

  • Rafanan, E.R.; Hutchinson, C.R.; Shen, B.
    Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O2 and one molecule of H2O (2000), Org. Lett., 2, 3225-3227.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.200 expression in Streptomyces lividans 1326 Streptomyces glaucescens
1.14.13.200 expression in Streptomyces lividans 1326 Streptomyces olivaceus

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.200 Streptomyces glaucescens
-
-
-
1.14.13.200 Streptomyces olivaceus Q9L4Y1
-
-
1.14.13.200 Streptomyces olivaceus Tue2353 Q9L4Y1
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.13.200 tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ = tetracenomycin C + 2 NAD(P)+ + H2O reaction proceeds via a monooxygenase-dioxygenase mechanism, deriving the 4- and 12a-OH groups of tetracenomycin C from two molecules of O2 and the 4a-OH group of etracenomycin C from a molecule of H2O Streptomyces glaucescens
a
1.14.13.200 tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ = tetracenomycin C + 2 NAD(P)+ + H2O reaction proceeds via a monooxygenase-dioxygenase mechanism, deriving the 4- and 12a-OH groups of tetracenomycin C from two molecules of O2 and the 4a-OH group of etracenomycin C from a molecule of H2O Streptomyces olivaceus
a